About 1 result found for searched term "JNJ-61432059 " (0.141 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M29120 | JNJ-61432059 | GluR |
| JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models. | ||
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